2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-119311
    Ketopioglitazone 146062-45-5 98%
    Pioglitazone ketone is an active metabolite of the PPARγ agonist Pioglitazone (HY-13956). Formation of pioglitazone ketone occurs primarly through cytochrome P450 (CYP) isoform CYP2C8-mediated metabolism of pioglitazone. Pioglitazone ketone (100 mg/kg in the diet) reduces blood glucose levels in a KKAy mouse model of type 2 diabetes.
    Ketopioglitazone
  • HY-119497
    SB251023 208842-53-9 98%
    SB251023 is a β3-adrenergic receptor agonist with pEC50 values of 7.14 and 6.91 for the β3a- and β3b-adrenergic receptors, respectively. SB251023 is capable of modulating cyclic AMP levels and extracellular acidification rate (EAR) in cells. It has potential application value in the study of cardiovascular diseases and metabolic-related disorders.
    SB251023
  • HY-119780
    BW1370U87 134476-36-1 98%
    BW1370U87 is an inhibitor of monoamine oxidase-A with anti-depression activity.
    BW1370U87
  • HY-119813
    (S,S)-Sinogliatin 1191996-10-7 98%
    (S,S)-Sinogliatin ((S,S)-HMS-5552) is the (S,S) -enantiomer of Sinogliatin. Sinogliatin is a glucokinase activator that can be used to study type 2 diabetes.
    (S,S)-Sinogliatin
  • HY-119991
    AHR-9294 84023-64-3 98%
    AHR-9294 is an inhibitor of the H+ pump enzyme and H, K-ATPase. AHR-9294 inhibits acid secretion in vivo.
    AHR-9294
  • HY-120117
    Rumbrin 148528-19-2 98%
    Rumbrin is a cytoprotective substance that preventsd cell death caused by calcium overload and exhibits a potent inhibitory activity against lipid peroxidation.
    Rumbrin
  • HY-120311
    Benadrostin 117241-60-8 98%
    Benadrostin is a Poly(ADP-ribose) synthetase inhibitor with an IC50 of 35 μM.
    Benadrostin
  • HY-120547
    UCB-11056 127390-77-6 98%
    UCB-11056 is a modulator of cyclic AMP generation. UCB-11056 can rapidly increase cyclic AMP levels in the rat brain in vivo and potentiate stimulated cyclic AMP formation in vitro. UCB-11056 does not stimulate cAMP formation on its own. UCB-11056 is a potential nootropic drug.
    UCB-11056
  • HY-120656
    Prostaglandin K2 275816-51-8 98%
    Prostaglandin K2 (PGK2) is the 9,11-diketone formed by the oxidation of PGE2 or PGD2. Whether this compound exists biologically is uncertain; it is known to be resistant to metabolism by 15-hydroxy PGDH in vitro.
    Prostaglandin K2
  • HY-12066R
    GSK1292263 (Standard) 1032823-75-8 98%
    GSK1292263 (Standard) is the analytical standard of GSK1292263. This product is intended for research and analytical applications. GSK-1292263 is an orally available GPR119 agonist with pEC50s of 6.9 and 6.7 for human and rat GPR119, respectively. GSK-1292263 can be used for the research of type 2 diabetes mellitus (T2DM).
    GSK1292263 (Standard)
  • HY-120886
    GW 2433 227941-61-9 98%
    GW 2433 is a dual PPARα and PPARδ agonist. GW 2433 has the potential for the study of type II diabetes and dyslipidemia.
    GW 2433
  • HY-120956
    Methyl stearidonate 73097-00-4 99.10%
    Methyl stearidonate is a secondary metabolite that can be isolated from Padina tenuis. Methyl stearidonate can be used for the research of type 2 diabetic.
    Methyl stearidonate
  • HY-120974
    α-lipoic acid derivative 1 691410-93-2 98%
    α-Lipoic Acid Derivative 1 (Compound AN-7) is an α-lipoic acid derivative that enhances glucose transport in skeletal muscle by releasing active α-lipoic acid (LA), significantly improving glucose metabolism. In L6 skeletal muscle cells, α-Lipoic Acid Derivative 1 significantly increases glucose transport rates, approximately 12 times more potent than the parent compound α-lipoic acid (HY-N0492). In a mild diabetic mouse model, 10 mg/kg of α-Lipoic Acid Derivative 1 administered for two weeks significantly reduced blood glucose levels by 39%. α-Lipoic Acid Derivative 1 shows significant potential in research related to glucose metabolism in diabetes.
    α-lipoic acid derivative 1
  • HY-120984
    Oleic Acid-2,6-diisopropylanilide 140112-65-8 99.98%
    AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol.1 Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC50 of 7 nM.2 When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%.
    Oleic Acid-2,6-diisopropylanilide
  • HY-121086
    BAY-588 1799759-24-2 98%
    BAY-588 is a selective inhibitor of GLUT1 with an IC50 value of 1.18μM.
    BAY-588
  • HY-121090
    FAAH-IN-9 288862-89-5 98%
    FAAH-IN-9 (compoud 59) is an irreversible oleoyl inhibitor of FAAH with Ki of 0.02 nM.
    FAAH-IN-9
  • HY-121174
    Alaternin 39723-40-5 98%
    Alaternin (Catharticin) is an anthraquinone compound with antioxidant and hepatoprotective activities. Alaternin has an inhibitory activity against hydroxyl radicals generated in a cell-free chemical system (FeSO4/H2O2) with an IC50 value of 3.05 μM. Alaternin exhibits hepatoprotective activity against Tacrine (HY-111338)-induced toxicity in human hepatic HepG2 cells with an EC50 value of 4.02 μM.
    Alaternin
  • HY-121315
    BRD4097 1550053-19-4 98%
    BRD4097 is an inhibitor of histone deacetylase (HDAC). BRD4097 acts by inhibiting the activity of HDACs, especially HDAC 1,2 and 3, through metal chelation and spatial rejection mechanisms, and this inhibition may help regulate gene expression and alter chromatin structure, thereby affecting a variety of biological processes. BRD4097 is used to study the role of HDAC in cholesterol metabolism and NPC1 diseases.
    BRD4097
  • HY-121423
    Dimethachlor 50563-36-5 98%
    Dimethachlor, a synthetic herbicide, inhibits the undesirable growth of weeds via the suppression of very long-chain fatty acid synthesis. Dimethachlor disrupts normal developmental processes via the induction of apoptosis and ROS production.
    Dimethachlor
  • HY-121448
    GW409544 258345-41-4 98%
    GW409544 is a potent PPARα and PPARγ activator, with EC50 values of 2.3 nM and 0.28 nM for PPARα and PPARγ, respectively. GW409544 can be used for the research of metabolic and cardiovascular diseases.
    GW409544
Cat. No. Product Name / Synonyms Application Reactivity